DNA Nanostructures for Electrophysiology

Understanding DNA based nanostructures.

We use molecular dynamics (MD) simulations to understand the structure, and stability of various Paranemic crossover (PX) DNA molecules and their topoisomer JX molecules, synthesized recently by Seeman and coworkers at New York University (NYU). Our studies include all atoms (4432 to 6215) of the PX structures with an explicit description of solvent and ions (for a total of up to 42,000 atoms) ...

Functionalized DNA nanostructures.

Binary DNA Nanostructures for Data Encryption

We present a simple and secure system for encrypting and decrypting information using DNA self-assembly. Binary data is encoded in the geometry of DNA nanostructures with two distinct conformations. Removing or leaving out a single component reduces these structures to an encrypted solution of ssDNA, whereas adding back this missing "decryption key" causes the spontaneous formation of the messa...

Design Tools for Reinforced 3D DNA Nanostructures

The field of DNA nanotechnology has grown since Nadrian Seeman founded it in 1980 creating a three dimensional structure made of DNA. The field has grown and there are many techniques to build these structures. One of them is DNA origami developed by P. Rothemund in 2006. This technology allows us to build two-dimensional and three-dimensional structures made with a single long strand called sc...

Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery

DNA-based nanostructures have been widely used in various applications due to their structural diversity, programmability, and uniform structures. Their intrinsic biocompatibility and biodegradability further motivates the investigation of DNA-based nanostructures as delivery vehicles. Incorporating AS1411 aptamers into DNA pyramids leads to enhanced intracellular uptake and selectively inhibit...